About the study

This study is evaluating if an investigational oral medicine may help to prevent or reduce signs and symptoms of dengue fever in adults 18 to 55 years of age when taken before and/or after exposure to a dengue virus.

The results of this study will help us learn more about dengue fever and contribute to the development of potential vaccines and treatments in the future. By choosing to participate, you are helping to advance science that could make a difference for billions of people around the world.

What to Expect

If you decide to take part in this research study, you will need to attend approximately 35 appointments with the study team over 4 months. These appointments may be a combination of in-person and over the phone. Most of the appointments will occur in the first month.

You will be randomly assigned to receive the investigational oral medicine (study drug) or placebo. The investigational medicine is being studied for use as a potential treatment or prevention for dengue fever. The placebo looks like the study drug but does not contain any active ingredients. You will take the study drug or placebo two times per day.

You will receive an injection containing a modified dengue virus that has been used in previous clinical trials. Your health will be closely monitored throughout the study, and you will receive appropriate medical care if severe symptoms develop.

If you are in the first group, you will take the study drug or placebo before receiving the dengue virus injection, and you will continue taking twice daily doses for 3 weeks after. If you are in the second group, you will not start taking the study drug or placebo until one week after your injection, and you will continue taking daily doses for 2 weeks. During this time, you will have regular visits with the study team so they can monitor your health, including potential side effects from the study drug or signs/ symptoms of dengue fever. The study team will also collect blood and saliva samples to measure the amount of dengue virus in your body.

Participating in this study is completely voluntary. You can choose to leave the study at any time, for any reason. Compensation up to $3,750 for study-related time and activities is available.

Learn More

Answer a few questions to see if you may qualify. To connect with a member of our study team, email the Study Coordinator at Trials@upstate.edu or call 315-464-9869.

Question 1 of 4

Are you 18 to 55 years old?

Question 2 of 4

If you are female, are you medically unable to have children (i.e., post-menopausal or post-surgical sterilization)? If you are male, are you and your female partner willing to use birth control throughout the study?

Question 3 of 4

Are you willing and able to attend approximately 22 clinic visits during your first month in the study?

Question 4 of 4

Are you willing to give blood and saliva samples during study visits?

So far – So good!

You appear to meet the pre-screening requirements for the Dengue Oral Prevention or Treatment Study! However, only the research study staff can fully determine if you qualify to enroll in the study. Please enter your information below and a study coordinator will contact you soon.

We're sorry, but you are not eligible at this time...

Thank you so much for your interest in the Dengue Oral Prevention or Treatment Study and for answering our questions. Contact your healthcare provider if you have any medical questions. Also, please consider entering your information below to be contacted about future clinical research opportunities.